Tuberculosis and leprosy infections in the Marshallese population of Arkansas, USA.

نویسندگان

  • Victor Manuel Cardenas
  • Mohammed S Orloff
  • Joseph Kaminaga
  • Irma Carrillo Cardenas
  • Joeline Brown
  • Sandra Hainline-Williams
  • Malcolm S Duthie
  • Angela C Gonzalez-Puche
  • Leonard Mukasa
  • Naveen Patil
  • Pearl Ann Mcelfish
  • Joseph H Bates
چکیده

The cross-immunity between tuberculosis and leprosy is unknown. The aim of this pilot study was to evaluate the occurrence of Mycobacterium tuberculosis and M. leprae infection in Marshallese adult volunteers in Springdale, Arkansas, U.S.A., a population that experiences high rates of leprosy and tuberculosis. We used immunodiagnostic testing for tuberculosis and leprosy infection and found significant prevalence of latent tuberculosis infection (19.0%), and asymptomatic Mycobacterium leprae infection (22.2%). We found a negative association between presence of antibodies to Mycobacterium leprae and a positive interferon-γ release assay for Mycobacterium tuberculosis infection, prevalence odds ratio = 0.1 (95% CI = 0.0, 0.9). Although these findings require confirmation on a larger scale, they are supportive of the existence of cross-immunity.

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عنوان ژورنال:
  • Leprosy review

دوره 87 1  شماره 

صفحات  -

تاریخ انتشار 2016